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Eskalith is used to treat the manic episodes of manic-depressive illness, a condition in which a person's mood swings from depression to excessive excitement. A manic episode may involve some or all of the following symptoms:

Aggressiveness, Elation, Urgent talking, Frenetic physical activity, Grandiose, Unrealistic ideas, Hostility, Little need for sleep, Poor judgment.

Once the mania subsides, Eskalith treatment may be continued over the long term, at a somewhat lower dosage, to prevent or reduce the intensity of future manic episodes.
Some doctors also prescribe lithium for premenstrual tension, eating disorders such as bulimia, certain movement disorders, and sexual addictions

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