Hyzaar (Losartan) is in a class of drugs called angiotensin II receptor antagonists.
Hydrochlorothiazide is a thiazide diuretic (water pill). It increases the amount of water and salt you lose in your urine. Hydrochlorothiazide is used to lower blood pressure and to decrease edema (swelling).

Losartan and hydrochlorothiazide is used to reduce hypertension (high blood pressure). Losartan and hydrochlorothiazide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about losartan and hydrochlorothiazide?

Do not take losartan and hydrochlorothiazide if you are pregnant or planning a pregnancy. When used during the second and third trimesters of pregnancy, losartan can cause injury and even death to the developing fetus. Notify your doctor immediately if you think you might be pregnant.

Use caution when driving, operating machinery, or performing other hazardous activities. Losartan and hydrochlorothiazide may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Also use caution when rising from a sitting or lying position. Use alcohol cautiously. Alcohol may further lower blood pressure and increase drowsiness and dizziness while you are taking losartan and hydrochlorothiazide.

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