Tadalafil

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Tadalafil is a phosphodiesterase type 5 inhibitor, more commonly known as a PDE5 inhibitor, which blocks the degradative action of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells lining the blood vessels supplying the sponge-like regions of erectile tissue, which contain most of the blood in the penis during an erection. Mainly it's clinically indicated for the treatment of erectile dysfunction although sometimes also for pulmonary hypertension which is a condition where blood vessels in the lungs become too narrow.

Common side effects include headache, flushing, stuffy/runny nose, indigestion, muscle aches and back pain, all reflecting the ability of Tadalafil to cause blood vessels to widen. Usually side effect go away after a few hours.

Tadalafil is not to be taken by those on any kind of nitrate medication or where cardiovascular risk factors are present.

Tadalafil is available under several trade names including: Apcalis, Cialis, Forzest, Sialis, Tadacip, Zydalis

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Tadalafil side effects

Like all medicines, Tadalafil can cause side effects although not everybody gets them. Side effects are generally mild or moderate in nature.
As a side effect described as "very common" in this leaflet, it means that it has been observed in at least one of the 10 patients taking this medicine. As a side effect described as "common" this means that it has been observed in more than 1 in 100 patients but less than 1 in 10 patients. As a side effect described as "uncommon" means that it has been observed in more than 1 in 1000 patients but less than 1 in 100 patients. As a side effect described as "rare", it means that it has been observed in more than 1 in 10 000 patients but less than 1 in 1000 patients.
Very common Tadalafil side effects in patients taking Tadalafil are headache.
Common side effects are back pain, muscle aches, facial flushing, nasal congestion, dizziness and indigestion.
UncommonTadalafil  side effects include allergic reactions, stomach pain, reflux, blurred vision, eye pain, increased sweating, palpitations, rapid heartbeat, high blood pressure, low blood pressure and chest pain. If you experience chest pain during or after sexual activity you should NOT use nitrates but you should seek immediate medical attention.
RareTadalafil  side effects in patients taking Tadalafil include fainting, seizures and temporary memory loss, swollen eyelids, red eyes, sudden förämring or loss of hearing, rashes and nosebleeds.
In rare cases, prolonged and possibly painful erection may occur after taking Tadalafil. If you get an erection that lasts longer than 4 hours, you should contact your doctor.
Heart attack and stroke have been reported rarely in men taking Tadalafil. Most, but not all, had known heart problems before taking this medicine. It is not possible to determine whether these events were directly related to Tadalafil.
Partial, sudden, temporary or permanent decrease or loss of vision in one or both eyes has been reported rarely.
A few more side effects, with the estimated frequency is unknown, which is not observed in clinical trials, have been reported in men taking Tadalafil. These side effects include migraines, facial swelling, severe skin rashes, disturbances in blood flow to the eyes, irregular heartbeat and angina and sudden cardiac death. Sudden decrease or loss of hearing has been reported.
In one animal species have been observed, which could indicate impairment of fertility. Subsequent studies in humans suggest that this effect is unlikely in humans, but a decrease in sperm concentration have been demonstrated in some men.
If any Tadalafil side effect worsens, or if you notice any side effects not listed here, ask your doctor or pharmacist.
More info on Tadalafil at MedlinePlus

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